Abstract Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly. as exemplified by the recent implementation of several vaccines against SARS-CoV-2. Using a bottom-up rational design approach. https://safeersappliancers.shop/product-category/siemens-lc87kbm60b-iq-300-built-in-79cm-3-speeds-b-chimney-cooker-hood-black/